A genetic screen identifies FAN1, a Fanconi anemia associated nuclease necessary for DNA interstrand crosslink repair

The Fanconi Anemia (FA) pathway is responsible for interstrand crosslink repair. At the heart of this pathway is the FANCI-FAND2 (ID) complex, which, upon ubiquitination by the FA core complex, travels to sites of damage to coordinate repair that includes nucleolytic modification of the DNA surround...

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Detalhes bibliográficos
Main Authors: Smogorzewska, Agata, Desetty, Rohini, Saito, Takamune T., Schlabach, Michael, Lach, Francis P., Sowa, Mathew E., Clark, Alan B., Kunkel, Thomas A., Harper, J. Wade, Colaiácovo, Monica P., Elledge, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919743/
https://ncbi.nlm.nih.gov/pubmed/20603073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.06.023
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