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Cellular response to DNA interstrand crosslinks: the Fanconi anemia pathway
Interstrand crosslinks (ICLs) are a highly toxic form of DNA damage. ICLs can interfere with vital biological processes requiring separation of the two DNA strands, such as replication and transcription. If ICLs are left unrepaired, it can lead to mutations, chromosome breakage and mitotic catastrop...
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| Published in: | Cell Mol Life Sci |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Springer International Publishing
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4951507/ https://ncbi.nlm.nih.gov/pubmed/27094386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-016-2218-x |
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