Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand cross-links

DNA interstrand cross-links (ICLs) are a form of DNA damage that requires the interplay of a number of repair proteins including those of the Fanconi anemia (FA) and the homologous recombination (HR) pathways. Pathogenic variants in the essential gene BRCA2/FANCD1, when monoallelic, predispose to br...

Full description

Saved in:
Bibliographic Details
Published in:Genes Dev
Main Authors: Rickman, Kimberly A., Noonan, Raymond J., Lach, Francis P., Sridhar, Sunandini, Wang, Anderson T., Abhyankar, Avinash, Huang, Athena, Kelly, Michael, Auerbach, Arleen D., Smogorzewska, Agata
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2020
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263144/
https://ncbi.nlm.nih.gov/pubmed/32354836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.336446.120
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items