DNA interstrand cross-link repair requires replication fork convergence

DNA interstrand cross-links (ICLs) prevent strand separation during DNA replication and transcription and are therefore extremely cytotoxic. In metazoans, a major pathway of ICL repair is coupled to DNA replication and requires the Fanconi anemia pathway. In most current models, collision of a singl...

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Publicado en:Nat Struct Mol Biol
Main Authors: Zhang, Jieqiong, Dewar, James M., Budzowska, Magda, Motnenko, Anna, Cohn, Martin A., Walter, Johannes C.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351167/
https://ncbi.nlm.nih.gov/pubmed/25643322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2956
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