Mechanism of replication-coupled DNA interstrand cross-link repair

DNA interstrand cross-links (ICLs) are toxic DNA lesions whose repair occurs in the S phase of metazoans via an unknown mechanism. Here, we describe a novel cell-free system based on Xenopus egg extracts that supports ICL repair. During DNA replication of a plasmid containing a site-specific ICL, tw...

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Detalhes bibliográficos
Main Authors: Räschle, Markus, Knipsheer, Puck, Enoiu, Milica, Angelov, Todor, Sun, Jingchuan, Griffith, Jack D., Ellenberger, Tom E., Schärer, Orlando D., Walter, Johannes C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748255/
https://ncbi.nlm.nih.gov/pubmed/18805090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.08.030
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