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Mechanism of replication-coupled DNA interstrand cross-link repair
DNA interstrand cross-links (ICLs) are toxic DNA lesions whose repair occurs in the S phase of metazoans via an unknown mechanism. Here, we describe a novel cell-free system based on Xenopus egg extracts that supports ICL repair. During DNA replication of a plasmid containing a site-specific ICL, tw...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2748255/ https://ncbi.nlm.nih.gov/pubmed/18805090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.08.030 |
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