Učitavanje...
Role of 53BP1 oligomerization in regulating double-strand break repair
Tumor suppressor p53-binding protein 1 (53BP1) regulates the repair of dysfunctional telomeres lacking the shelterin protein TRF2 by promoting their mobility, their nonhomologous end-joining (NHEJ), and, as we show here, by blocking 5′ resection by CtIP. We report that these functions of 53BP1 requi...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2013
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3568336/ https://ncbi.nlm.nih.gov/pubmed/23345425 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222617110 |
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