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Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination
In B cells, Ig class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), the activity of which leads to DNA double-strand breaks (DSBs) within IgH switch (S) regions. Preferential targeting of AID-mediated DSBs to S sequences is critical for allowing diversificati...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5724247/ https://ncbi.nlm.nih.gov/pubmed/29158395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701366114 |
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