Characterization of the EZH2-MMSET Histone Methyltransferase Regulatory Axis in Cancer

Histone methyltransferases (HMTases), as chromatin modifiers, regulate the transcriptomic landscape in normal development as well in diseases such as cancer. Here, we molecularly order two HMTases, EZH2 and MMSET that have established genetic links to oncogenesis. EZH2, which mediates histone H3K27...

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主要な著者: Asangani, Irfan A., Ateeq, Bushra, Cao, Qi, Dodson, Lois, Pandhi, Mithil, Kunju, Lakshmi P., Mehra, Rohit, Lonigro, Robert J., Siddiqui, Javed, Palanisamy, Nallasivam, Wu, Yi-Mi, Cao, Xuhong, Kim, Jung H., Zhao, Meng, Qin, Zhaohui S., Iyer, Mathew K., Maher, Christopher A., Kumar-Sinha, Chandan, Varambally, Sooryanarayana, Chinnaiyan, Arul M.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547524/
https://ncbi.nlm.nih.gov/pubmed/23159737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.10.008
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