Characterization of the EZH2-MMSET Histone Methyltransferase Regulatory Axis in Cancer

Histone methyltransferases (HMTases), as chromatin modifiers, regulate the transcriptomic landscape in normal development as well in diseases such as cancer. Here, we molecularly order two HMTases, EZH2 and MMSET that have established genetic links to oncogenesis. EZH2, which mediates histone H3K27...

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Détails bibliographiques
Auteurs principaux: Asangani, Irfan A., Ateeq, Bushra, Cao, Qi, Dodson, Lois, Pandhi, Mithil, Kunju, Lakshmi P., Mehra, Rohit, Lonigro, Robert J., Siddiqui, Javed, Palanisamy, Nallasivam, Wu, Yi-Mi, Cao, Xuhong, Kim, Jung H., Zhao, Meng, Qin, Zhaohui S., Iyer, Mathew K., Maher, Christopher A., Kumar-Sinha, Chandan, Varambally, Sooryanarayana, Chinnaiyan, Arul M.
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547524/
https://ncbi.nlm.nih.gov/pubmed/23159737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.10.008
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