Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase that contributes to the epigenetic silencing of target genes and that regulates the survival and metastasis of cancer cells. EZH2 is overexpressed in aggressive solid tumors by mechanisms that remain unclear. Here, we show t...

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Bibliographic Details
Main Authors: Varambally, Sooryanarayana, Cao, Qi, Mani, Ram-Shankar, Shankar, Sunita, Wang, Xiaosong, Ateeq, Bushra, Laxman, Bharathi, Cao, Xuhong, Jing, Xiaojun, Ramnarayanan, Kalpana, Brenner, J. Chad, Yu, Jindan, Kim, Jung H., Han, Bo, Tan, Patrick, Kumar-Sinha, Chandan, Lonigro, Robert J., Palanisamy, Nallasivam, Maher, Christopher A., Chinnaiyan, Arul M.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684823/
https://ncbi.nlm.nih.gov/pubmed/19008416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1165395
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