Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase that contributes to the epigenetic silencing of target genes and that regulates the survival and metastasis of cancer cells. EZH2 is overexpressed in aggressive solid tumors by mechanisms that remain unclear. Here, we show t...

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Autors principals: Varambally, Sooryanarayana, Cao, Qi, Mani, Ram-Shankar, Shankar, Sunita, Wang, Xiaosong, Ateeq, Bushra, Laxman, Bharathi, Cao, Xuhong, Jing, Xiaojun, Ramnarayanan, Kalpana, Brenner, J. Chad, Yu, Jindan, Kim, Jung H., Han, Bo, Tan, Patrick, Kumar-Sinha, Chandan, Lonigro, Robert J., Palanisamy, Nallasivam, Maher, Christopher A., Chinnaiyan, Arul M.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684823/
https://ncbi.nlm.nih.gov/pubmed/19008416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1165395
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