The tumor suppressor gene rap1GAP is silenced by mir-101-mediated EZH2 overexpression in invasive squamous cell carcinoma

Rap1GAP is a critical tumor suppressor gene that is down-regulated in multiple aggressive cancers such as head and neck squamous cell carcinoma, melanoma and pancreatic cancer. However, the mechanistic basis of rap1GAP down-regulation in cancers is poorly understood. By employing an integrative appr...

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Hlavní autoři: Banerjee, Rajat, Mani, Ram-Shankar, Russo, Nickole, Scanlon, Christina S., Tsodikov, Alexander, Jing, Xiaojun, Cao, Qi, Palanisamy, Nallasivam, Metwally, Tarek, Inglehart, Ronald C., Tomlins, Scott, Bradford, Carol, Carey, Thomas, Wolf, Gregory, Kalyana-Sundaram, Shanker, Chinnaiyan, Arul M., Varambally, Sooryanarayana, D’Silva, Nisha J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154567/
https://ncbi.nlm.nih.gov/pubmed/21532618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.141
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