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TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer
Head and neck cancer (SCCHN) is a common, aggressive, treatment-resistant cancer with a high recurrence rate and mortality, but the mechanism of treatment-resistance remains unclear. Here we describe a mechanism where the AAA-ATPase TRIP13 promotes treatment-resistance. Overexpression of TRIP13 in n...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , , , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2014
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4130352/ https://ncbi.nlm.nih.gov/pubmed/25078033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5527 |
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