TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer

Head and neck cancer (SCCHN) is a common, aggressive, treatment-resistant cancer with a high recurrence rate and mortality, but the mechanism of treatment-resistance remains unclear. Here we describe a mechanism where the AAA-ATPase TRIP13 promotes treatment-resistance. Overexpression of TRIP13 in n...

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Main Authors: Banerjee, Rajat, Russo, Nickole, Liu, Min, Basrur, Venkatesha, Bellile, Emily, Palanisamy, Nallasivam, Scanlon, Christina S., van Tubergen, Elizabeth, Inglehart, Ronald C., Metwally, Tarek, Mani, Ram-Shankar, Yocum, Anastasia, Nyati, Mukesh K., Castilho, Rogerio M., Varambally, Sooryanarayana, Chinnaiyan, Arul M., D’Silva, Nisha J.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4130352/
https://ncbi.nlm.nih.gov/pubmed/25078033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5527
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