Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma

MicroRNAs (miRs) play a key role in cancer etiology by coordinately repressing numerous target genes involved in cell proliferation, migration and invasion. The genomic region in chromosome 9p21 that encompasses miR-31 is frequently deleted in solid cancers including melanoma; however the expression...

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Main Authors: Asangani, Irfan A., Harms, Paul W., Dodson, Lois, Pandhi, Mithil, Kunju, Lakshmi P., Maher, Christopher A., Fullen, Douglas R., Johnson, Timothy M., Giordano, Thomas J., Palanisamy, Nallasivam, Chinnaiyan, Arul M.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2012
Teme:
Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663613/
https://ncbi.nlm.nih.gov/pubmed/22948084
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