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Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases

Although great progress has been made in the characterization of off-target effects of engineered nucleases, sensitive and unbiased genome-wide methods for the detection of off-target cleavage events and potential collateral damage are still lacking. Here we describe a linear amplification–mediated...

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Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Frock, Richard L., Hu, Jiazhi, Meyers, Robin M., Ho, Yu-Jui, Kii, Erina, Alt, Frederick W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4320661/
https://ncbi.nlm.nih.gov/pubmed/25503383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3101
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