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Targeting DNA Double-Strand Breaks with TAL Effector Nucleases
Engineered nucleases that cleave specific DNA sequences in vivo are valuable reagents for targeted mutagenesis. Here we report a new class of sequence-specific nucleases created by fusing transcription activator-like effectors (TALEs) to the catalytic domain of the FokI endonuclease. Both native and...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Genetics Society of America
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2942870/ https://ncbi.nlm.nih.gov/pubmed/20660643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.110.120717 |
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