Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

Engineered nucleases that cleave specific DNA sequences in vivo are valuable reagents for targeted mutagenesis. Here we report a new class of sequence-specific nucleases created by fusing transcription activator-like effectors (TALEs) to the catalytic domain of the FokI endonuclease. Both native and...

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Bibliographic Details
Main Authors: Christian, Michelle, Cermak, Tomas, Doyle, Erin L., Schmidt, Clarice, Zhang, Feng, Hummel, Aaron, Bogdanove, Adam J., Voytas, Daniel F.
Format: Artigo
Language:Inglês
Published: Genetics Society of America 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2942870/
https://ncbi.nlm.nih.gov/pubmed/20660643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.110.120717
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