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Convergent Transcription At Intragenic Super-Enhancers Targets AID-initiated Genomic Instability
Activation-induced cytidine deaminase (AID) initiates both somatic hypermutation (SHM) for antibody affinity maturation and DNA breakage for antibody class switch recombination (CSR) via transcription-dependent cytidine deamination of single stranded DNA targets. While largely specific for immunoglo...
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| Udgivet i: | Cell |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4322776/ https://ncbi.nlm.nih.gov/pubmed/25483776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.11.014 |
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