Convergent Transcription At Intragenic Super-Enhancers Targets AID-initiated Genomic Instability

Activation-induced cytidine deaminase (AID) initiates both somatic hypermutation (SHM) for antibody affinity maturation and DNA breakage for antibody class switch recombination (CSR) via transcription-dependent cytidine deamination of single stranded DNA targets. While largely specific for immunoglo...

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Udgivet i:Cell
Main Authors: Meng, Fei-Long, Du, Zhou, Federation, Alexander, Hu, Jiazhi, Wang, Qiao, Kieffer-Kwon, Kyong-Rim, Meyers, Robin M., Amor, Corina, Wasserman, Caitlyn R., Neuberg, Donna, Casellas, Rafael, Nussenzweig, Michel C., Bradner, James E., Liu, X. Shirley, Alt, Frederick W.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322776/
https://ncbi.nlm.nih.gov/pubmed/25483776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.11.014
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