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Microbial colonization influences early B-lineage development in the gut lamina propria
The RAG1/RAG2 endonuclease ("RAG") initiates the V(D)J recombination reaction that assembles Ig heavy (IgH) and light (IgL) chain variable region exons from germline gene segments to generate primary antibody repertoires(1). IgH V(D)J assembly occurs in progenitor (pro-) B cells followed b...
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Main Authors: | , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3807868/ https://ncbi.nlm.nih.gov/pubmed/23965619 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12496 |
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