LRRK2 and ubiquitination: implications for kinase inhibitor therapy

od Melrose, Heather L.
Wydane w Biochem J (2015)

Human LRRK2 G2019S mutation represses post-synaptic protein PSD95 and causes cognitive impairment in transgenic mice

od Adeosun, Samuel O., Hou, Xu, Zheng, Baoying, Melrose, Heather L., Mosley, Thomas, Wang, Jun Ming
Wydane w Neurobiol Learn Mem (2017)

A comparative study of Lrrk2 function in primary neuronal cultures

od Dächsel, Justus C., Behrouz, Bahareh, Yue, Mei, Beevers, Joel E., Melrose, Heather L., Farrer, Matthew J.
Wydane 2010

Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia

od Maekawa, Tatsunori, Sasaoka, Toshikuni, Azuma, Sadahiro, Ichikawa, Takafumi, Melrose, Heather L., Farrer, Matthew J., Obata, Fumiya
Wydane w BMC Neurosci (2016)

ER stress response plays an important role in aggregation of α-synuclein

od Jiang, Peizhou, Gan, Ming, Ebrahim, Abdul Shukkur, Lin, Wen-Lang, Melrose, Heather L, Yen, Shu-Hui C
Wydane 2010

Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain

od Liu, Chia-Chen, Hu, Jin, Tsai, Chih-Wei, Yue, Mei, Melrose, Heather L., Kanekiyo, Takahisa, Bu, Guojun
Wydane w J Neurosci (2015)

Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity

od Kluss, Jillian H., Conti, Melissa M., Kaganovich, Alice, Beilina, Aleksandra, Melrose, Heather L., Cookson, Mark R., Mamais, Adamantios
Wydane w NPJ Parkinsons Dis (2018)

Differential LRRK2 Expression in the Cortex, Striatum, and Substantia Nigra in Transgenic and Nontransgenic Rodents

od West, Andrew B., Cowell, Rita M., Daher, João P.L., Moehle, Mark S., Hinkle, Kelly M., Melrose, Heather L., Standaert, David G., Volpicelli-Daley, Laura A.
Wydane 2014

LRRK2 phosphorylates novel tau epitopes and promotes tauopathy

od Bailey, Rachel M., Covy, Jason P., Melrose, Heather L., Rousseau, Linda, Watkinson, Ruth, Knight, Joshua, Miles, Sarah, Farrer, Matthew J., Dickson, Dennis W., Giasson, Benoit I., Lewis, Jada
Wydane 2013

LRRK2 contributes to monocyte dysregulation in Parkinson’s disease

od Bliederhaeuser, Corinna, Zondler, Lisa, Grozdanov, Veselin, Ruf, Wolfgang P., Brenner, David, Melrose, Heather L., Bauer, Peter, Ludolph, Albert C., Gillardon, Frank, Kassubek, Jan, Weishaupt, Jochen H., Danzer, Karin M.
Wydane w Acta Neuropathol Commun (2016)

Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons

od Schapansky, Jason, Khasnavis, Saurabh, DeAndrade, Mark P., Nardozzi, Jonathan D., Falkson, Samuel R., Boyd, Justin D., Sanderson, John B., Bartels, Tim, Melrose, Heather L., LaVoie, Matthew J.
Wydane w Neurobiol Dis (2017)

RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase–mediated centrosomal cohesion and ciliogenesis deficits

od Lara Ordónez, Antonio Jesús, Fernández, Belén, Fdez, Elena, Romo-Lozano, María, Madero-Pérez, Jesús, Lobbestael, Evy, Baekelandt, Veerle, Aiastui, Ana, López de Munaín, Adolfo, Melrose, Heather L, Civiero, Laura, Hilfiker, Sabine
Wydane w Hum Mol Genet (2019)

Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice

od Pellegrini, Laura, Hauser, David N, Li, Yan, Mamais, Adamantios, Beilina, Alexandra, Kumaran, Ravindran, Wetzel, Andrea, Nixon-Abell, Jonathon, Heaton, George, Rudenko, Iakov, Alkaslasi, Mor, Ivanina, Natalie, Melrose, Heather L, Cookson, Mark R, Harvey, Kirsten
Wydane w Hum Mol Genet (2018)

Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies

od Davies, Paul, Hinkle, Kelly M., Sukar, Nour N., Sepulveda, Bryan, Mesias, Roxana, Serrano, Geidy, Alessi, Dario R., Beach, Thomas G., Benson, Deanna L., White, Charles L., Cowell, Rita M., Das, Sonal S., West, Andrew B., Melrose, Heather L.
Wydane 2013

LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors

od Hinkle, Kelly M, Yue, Mei, Behrouz, Bahareh, Dächsel, Justus C, Lincoln, Sarah J, Bowles, Erin E, Beevers, Joel E, Dugger, Brittany, Winner, Beate, Prots, Iryna, Kent, Caroline B, Nishioka, Kenya, Lin, Wen-Lang, Dickson, Dennis W, Janus, Christopher J, Farrer, Matthew J, Melrose, Heather L
Wydane 2012

LINGO1 rs9652490 is associated with Essential Tremor and Parkinson Disease

od Vilariño-Güell, Carles, Ross, Owen A., Wider, Christian, Jasinska-Myga, Barbara, Cobb, Stephanie A., Soto-Ortolaza, Alexandra I., Kachergus, Jennifer M., Keeling, Brett H., Dachsel, Justus C., Melrose, Heather L., Behrouz, Bahareh, Wszolek, Zbigniew K., Uitti, Ryan J., Aasly, Jan O, Rajput, Alex, Farrer, Matthew J.
Wydane 2009

Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology

od Hou, Xu, Watzlawik, Jens O., Cook, Casey, Liu, Chia‐Chen, Kang, Silvia S., Lin, Wen‐Lang, DeTure, Michael, Heckman, Michael G., Diehl, Nancy N., Al‐Shaikh, Fadi S. Hanna, Walton, Ronald L., Ross, Owen A., Melrose, Heather L., Ertekin‐Taner, Nilüfer, Bu, Guojun, Petrucelli, Leonard, Fryer, John D., Murray, Melissa E., Dickson, Dennis W., Fiesel, Fabienne C., Springer, Wolfdieter
Wydane w Alzheimers Dement (2020)

VPS35 Mutations in Parkinson Disease

od Vilariño-Güell, Carles, Wider, Christian, Ross, Owen A., Dachsel, Justus C., Kachergus, Jennifer M., Lincoln, Sarah J., Soto-Ortolaza, Alexandra I., Cobb, Stephanie A., Wilhoite, Greggory J., Bacon, Justin A., Behrouz, Bahareh, Melrose, Heather L., Hentati, Emna, Puschmann, Andreas, Evans, Daniel M., Conibear, Elizabeth, Wasserman, Wyeth W., Aasly, Jan O., Burkhard, Pierre R., Djaldetti, Ruth, Ghika, Joseph, Hentati, Faycal, Krygowska-Wajs, Anna, Lynch, Tim, Melamed, Eldad, Rajput, Alex, Rajput, Ali H., Solida, Alessandra, Wu, Ruey-Meei, Uitti, Ryan J., Wszolek, Zbigniew K., Vingerhoets, François, Farrer, Matthew J.
Wydane 2011

VPS35 Mutations in Parkinson Disease

od Vilariño-Güell, Carles, Wider, Christian, Ross, Owen A., Dachsel, Justus C., Kachergus, Jennifer M., Lincoln, Sarah J., Soto-Ortolaza, Alexandra I., Cobb, Stephanie A., Wilhoite, Greggory J., Bacon, Justin A., Behrouz, Bahareh, Melrose, Heather L., Hentati, Emna, Puschmann, Andreas, Evans, Daniel M., Conibear, Elizabeth, Wasserman, Wyeth W., Aasly, Jan O., Burkhard, Pierre R., Djaldetti, Ruth, Ghika, Joseph, Hentati, Faycal, Krygowska-Wajs, Anna, Lynch, Tim, Melamed, Eldad, Rajput, Alex, Rajput, Ali H., Solida, Alessandra, Wu, Ruey-Meei, Uitti, Ryan J., Wszolek, Zbigniew K., Vingerhoets, François, Farrer, Matthew J.
Wydane 2011

Translation Initiator EIF4G1 Mutations in Familial Parkinson Disease

od Chartier-Harlin, Marie-Christine, Dachsel, Justus C., Vilariño-Güell, Carles, Lincoln, Sarah J., Leprêtre, Frédéric, Hulihan, Mary M., Kachergus, Jennifer, Milnerwood, Austen J., Tapia, Lucia, Song, Mee-Sook, Le Rhun, Emilie, Mutez, Eugénie, Larvor, Lydie, Duflot, Aurélie, Vanbesien-Mailliot, Christel, Kreisler, Alexandre, Ross, Owen A., Nishioka, Kenya, Soto-Ortolaza, Alexandra I., Cobb, Stephanie A., Melrose, Heather L., Behrouz, Bahareh, Keeling, Brett H., Bacon, Justin A., Hentati, Emna, Williams, Lindsey, Yanagiya, Akiko, Sonenberg, Nahum, Lockhart, Paul J., Zubair, Abba C., Uitti, Ryan J., Aasly, Jan O., Krygowska-Wajs, Anna, Opala, Grzegorz, Wszolek, Zbigniew K., Frigerio, Roberta, Maraganore, Demetrius M., Gosal, David, Lynch, Tim, Hutchinson, Michael, Bentivoglio, Anna Rita, Valente, Enza Maria, Nichols, William C., Pankratz, Nathan, Foroud, Tatiana, Gibson, Rachel A., Hentati, Faycal, Dickson, Dennis W., Destée, Alain, Farrer, Matthew J.
Wydane 2011