Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies

Missense mutations in LRRK2 (leucine-rich repeat kinase 2) are a major cause of PD (Parkinson's disease). Several antibodies against LRRK2 have been developed, but results using these polyclonal antibodies have varied widely leading to conflicting conclusions. To address this challenge, the Mic...

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Main Authors: Davies, Paul, Hinkle, Kelly M., Sukar, Nour N., Sepulveda, Bryan, Mesias, Roxana, Serrano, Geidy, Alessi, Dario R., Beach, Thomas G., Benson, Deanna L., White, Charles L., Cowell, Rita M., Das, Sonal S., West, Andrew B., Melrose, Heather L.
Format: Artigo
Jezik:Inglês
Izdano: Portland Press Ltd. 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682752/
https://ncbi.nlm.nih.gov/pubmed/23560750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20121742
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