LRRK2 Inhibition Attenuates Microglial Inflammatory Responses

Missense mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset Parkinson's disease (PD), and common genetic variation in LRRK2 modifies susceptibility to Crohn's disease and leprosy. High levels of LRRK2 expression in peripheral monocytes and macrophages suggest a role for LRR...

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Autors principals: Moehle, Mark S., Webber, Philip J., Tse, Tonia, Sukar, Nour, Standaert, David G., DeSilva, Tara M., Cowell, Rita M., West, Andrew B.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2012
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532034/
https://ncbi.nlm.nih.gov/pubmed/22302802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5601-11.2012
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