LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase

In response to brain injury, microglia rapidly extend processes that isolate lesion sites and protect the brain from further injury. Here we report that microglia carrying a pathogenic mutation in the Parkinson's disease (PD)-associated gene, G2019S-LRRK2 (GS-Tg microglia), show retarded ADP-in...

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Udgivet i:Nat Commun
Main Authors: Choi, Insup, Kim, Beomsue, Byun, Ji-Won, Baik, Sung Hoon, Huh, Yun Hyun, Kim, Jong-Hyeon, Mook-Jung, Inhee, Song, Woo Keun, Shin, Joo-Ho, Seo, Hyemyung, Suh, Young Ho, Jou, Ilo, Park, Sang Myun, Kang, Ho Chul, Joe, Eun-Hye
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647842/
https://ncbi.nlm.nih.gov/pubmed/26365310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9255
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