LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase

In response to brain injury, microglia rapidly extend processes that isolate lesion sites and protect the brain from further injury. Here we report that microglia carrying a pathogenic mutation in the Parkinson's disease (PD)-associated gene, G2019S-LRRK2 (GS-Tg microglia), show retarded ADP-in...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Choi, Insup, Kim, Beomsue, Byun, Ji-Won, Baik, Sung Hoon, Huh, Yun Hyun, Kim, Jong-Hyeon, Mook-Jung, Inhee, Song, Woo Keun, Shin, Joo-Ho, Seo, Hyemyung, Suh, Young Ho, Jou, Ilo, Park, Sang Myun, Kang, Ho Chul, Joe, Eun-Hye
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647842/
https://ncbi.nlm.nih.gov/pubmed/26365310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9255
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados