LRRK2 Inhibits FAK Activity by Promoting FERM-mediated Autoinhibition of FAK and Recruiting the Tyrosine Phosphatase, SHP-2

Mutation of leucine-rich repeat kinase 2 (LRRK2) causes an autosomal dominant and late-onset familial Parkinson's disease (PD). Recently, we reported that LRRK2 directly binds to and phosphorylates the threonine 474 (T474)-containing Thr-X-Arg(Lys) (TXR) motif of focal adhesion kinase (FAK), th...

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Detalhes bibliográficos
Publicado no:Exp Neurobiol
Main Authors: Choi, Insup, Byun, Ji-won, Park, Sang Myun, Jou, Ilo, Joe, Eun-Hye
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Society for Brain and Neural Science 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081473/
https://ncbi.nlm.nih.gov/pubmed/27790061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5607/en.2016.25.5.269
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