Small heterodimer partner (SHP) aggravates ER stress in Parkinson’s disease-linked LRRK2 mutant astrocyte by regulating XBP1 SUMOylation

BACKGROUND: Endoplasmic reticulum (ER) stress is a common feature of Parkinson’s disease (PD), and several PD-related genes are responsible for ER dysfunction. Recent studies suggested LRRK2-G2019S, a pathogenic mutation in the PD-associated gene LRRK2, cause ER dysfunction, and could thereby contri...

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Vydáno v:J Biomed Sci
Hlavní autoři: Lee, Jee Hoon, Han, Ji-hye, Joe, Eun-hye, Jou, Ilo
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8261914/
https://ncbi.nlm.nih.gov/pubmed/34229656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-021-00747-1
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