Impaired Inflammatory Responses in Murine Lrrk2-Knockdown Brain Microglia

LRRK2, a Parkinson's disease associated gene, is highly expressed in microglia in addition to neurons; however, its function in microglia has not been evaluated. Using Lrrk2 knockdown (Lrrk2-KD) murine microglia prepared by lentiviral-mediated transfer of Lrrk2-specific small inhibitory hairpin...

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Detalhes bibliográficos
Main Authors: Kim, Beomsue, Yang, Myung-Soon, Choi, Dongjoo, Kim, Jong-Hyeon, Kim, Hye-Sun, Seol, Wongi, Choi, Sangdun, Jou, Ilo, Kim, Eun-Young, Joe, Eun-hye
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322140/
https://ncbi.nlm.nih.gov/pubmed/22496842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034693
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