LRRK2 in Parkinson’s Disease: Function in Cells and Neurodegeneration

Por Webber, Philip J., West, Andrew B.
Publicado em 2009

Dependence of Leucine-rich Repeat Kinase 2 (LRRK2) Kinase Activity on Dimerization

Por Sen, Saurabh, Webber, Philip J., West, Andrew B.
Publicado em 2009

GTPase Activity and Neuronal Toxicity of Parkinson's Disease–Associated LRRK2 Is Regulated by ArfGAP1

Por Stafa, Klodjan, Trancikova, Alzbeta, Webber, Philip J., Glauser, Liliane, West, Andrew B., Moore, Darren J.
Publicado em 2012

Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells

Por Webber, Philip J., Park, Chanhee, Qui, Min, Ramalingam, Suresh S., Khuri, Fadlo R., Fu, Haian, Du, Yuhong
Publicado no Oncoscience (2015)

Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities

Por Webber, Philip J., Smith, Archer D., Sen, Saurabh, Renfrow, Matthew B., Mobley, James A., West, Andrew B.
Publicado em 2011

Phosphorylation of 4E-BP1 in the Mammalian Brain Is Not Altered by LRRK2 Expression or Pathogenic Mutations

Por Trancikova, Alzbeta, Mamais, Adamantios, Webber, Philip J., Stafa, Klodjan, Tsika, Elpida, Glauser, Liliane, West, Andrew B., Bandopadhyay, Rina, Moore, Darren J.
Publicado em 2012

LRRK2 Inhibition Attenuates Microglial Inflammatory Responses

Por Moehle, Mark S., Webber, Philip J., Tse, Tonia, Sukar, Nour, Standaert, David G., DeSilva, Tara M., Cowell, Rita M., West, Andrew B.
Publicado em 2012

Investigating Bacterial Sources of Toxicity as an Environmental Contributor to Dopaminergic Neurodegeneration

Por Caldwell, Kim A., Tucci, Michelle L., Armagost, Jafa, Hodges, Tyler W., Chen, Jue, Memon, Shermeen B., Blalock, Jeana E., DeLeon, Susan M., Findlay, Robert H., Ruan, Qingmin, Webber, Philip J., Standaert, David G., Olson, Julie B., Caldwell, Guy A.
Publicado em 2009

Novel Pathogenic Lrrk2 p.Asn1437His substitution in familial Parkinson’s disease

Por Aasly, Jan O., Vilariño-Güell, Carles, Dachsel, Justus C., Webber, Philip J., West, Andrew B., Haugarvoll, Kristoffer, Johansen, Krisztina K., Toft, Mathias, Nutt, John G., Payami, Haydeh, Kachergus, Jennifer M., Lincoln, Sarah J., Felic, Amela, Wider, Christian, Soto-Ortolaza, Alexandra I., Cobb, Stephanie A., White, Linda R., Ross, Owen A., Farrer, Matthew J.
Publicado em 2010

LRRK2 secretion in exosomes is regulated by 14-3-3

Por Fraser, Kyle B., Moehle, Mark S., Daher, João P.L., Webber, Philip J., Williams, Jeri Y., Stewart, Carrie A., Yacoubian, Talene A., Cowell, Rita M., Dokland, Terje, Ye, Tong, Chen, Dongquan, Siegal, Gene P., Galemmo, Robert A., Tsika, Elpida, Moore, Darren J., Standaert, David G., Kojima, Kyoko, Mobley, James A., West, Andrew B.
Publicado em 2013

Structural basis for KDM5A histone lysine demethylase inhibition by diverse compounds

Por Horton, John R., Liu, Xu, Gale, Molly, Wu, Lizhen, Shanks, John R., Zhang, Xing, Webber, Philip J., Bell, Joshua S.K., Kales, Stephen C, Mott, Bryan T, Rai, Ganesha, Jansen, Daniel J, Henderson, Mark J, Urban, Daniel J, Hall, Matthew D, Simeonov, Anton, Maloney, David J, Johns, Margaret A., Fu, Haian, Jadhav, Ajit, Vertino, Paula M., Yan, Qin, Cheng, Xiaodong
Publicado no Cell Chem Biol (2016)