Structural basis for KDM5A histone lysine demethylase inhibition by diverse compounds

The KDM5/JARID1 family of Fe(II)- and α-ketoglutarate-dependent demethylases removes methyl groups from methylated lysine 4 of histone H3. Accumulating evidence supports a role for KDM5 family members as oncogenic drivers. We compare the in vitro inhibitory properties and binding affinity of ten div...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Cell Chem Biol
Autors principals: Horton, John R., Liu, Xu, Gale, Molly, Wu, Lizhen, Shanks, John R., Zhang, Xing, Webber, Philip J., Bell, Joshua S.K., Kales, Stephen C, Mott, Bryan T, Rai, Ganesha, Jansen, Daniel J, Henderson, Mark J, Urban, Daniel J, Hall, Matthew D, Simeonov, Anton, Maloney, David J, Johns, Margaret A., Fu, Haian, Jadhav, Ajit, Vertino, Paula M., Yan, Qin, Cheng, Xiaodong
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958579/
https://ncbi.nlm.nih.gov/pubmed/27427228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.06.006
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars