Structural basis for KDM5A histone lysine demethylase inhibition by diverse compounds

The KDM5/JARID1 family of Fe(II)- and α-ketoglutarate-dependent demethylases removes methyl groups from methylated lysine 4 of histone H3. Accumulating evidence supports a role for KDM5 family members as oncogenic drivers. We compare the in vitro inhibitory properties and binding affinity of ten div...

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Publicado en:Cell Chem Biol
Autores principales: Horton, John R., Liu, Xu, Gale, Molly, Wu, Lizhen, Shanks, John R., Zhang, Xing, Webber, Philip J., Bell, Joshua S.K., Kales, Stephen C, Mott, Bryan T, Rai, Ganesha, Jansen, Daniel J, Henderson, Mark J, Urban, Daniel J, Hall, Matthew D, Simeonov, Anton, Maloney, David J, Johns, Margaret A., Fu, Haian, Jadhav, Ajit, Vertino, Paula M., Yan, Qin, Cheng, Xiaodong
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958579/
https://ncbi.nlm.nih.gov/pubmed/27427228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.06.006
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