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KDM5 histone demethylase activity links cellular transcriptomic heterogeneity to therapeutic resistance
Members of the KDM5 histone H3 lysine 4 demethylase family are associated with therapeutic resistance, including endocrine resistance in breast cancer, but the underlying mechanism is poorly defined. Here we show that genetic deletion of KDM5A/B or inhibition of KDM5 activity increases sensitivity t...
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| Gepubliceerd in: | Cancer Cell |
|---|---|
| Hoofdauteurs: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6310147/ https://ncbi.nlm.nih.gov/pubmed/30472020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.10.014 |
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