KDM5 histone demethylase activity links cellular transcriptomic heterogeneity to therapeutic resistance

Members of the KDM5 histone H3 lysine 4 demethylase family are associated with therapeutic resistance, including endocrine resistance in breast cancer, but the underlying mechanism is poorly defined. Here we show that genetic deletion of KDM5A/B or inhibition of KDM5 activity increases sensitivity t...

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Pubblicato in:Cancer Cell
Autori principali: Hinohara, Kunihiko, Wu, Hua-Jun, Vigneau, Sébastien, McDonald, Thomas O., Igarashi, Kyomi J., Yamamoto, Kimiyo N., Madsen, Thomas, Fassl, Anne, Egri, Shawn B., Papanastasiou, Malvina, Ding, Lina, Peluffo, Guillermo, Cohen, Ofir, Kales, Stephen C., Lal-Nag, Madhu, Rai, Ganesha, Maloney, David J., Jadhav, Ajit, Simeonov, Anton, Wagle, Nikhil, Brown, Myles, Meissner, Alexander, Sicinski, Piotr, Jaffe, Jacob D., Jeselsohn, Rinath, Gimelbrant, Alexander A., Michor, Franziska, Polyak, Kornelia
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310147/
https://ncbi.nlm.nih.gov/pubmed/30472020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.10.014
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