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Dependence of Leucine-rich Repeat Kinase 2 (LRRK2) Kinase Activity on Dimerization

Dominant missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common known genetic cause of Parkinson disease. LRRK2 encodes a serine/threonine protein kinase, and pathogenic mutations may increase kinase activity. Intrinsic GTP binding in the GTPase domain may govern kin...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Sen, Saurabh, Webber, Philip J., West, Andrew B.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2009
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794750/
https://ncbi.nlm.nih.gov/pubmed/19826009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.025437
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