Identification and Characterization of a Leucine-Rich Repeat Kinase 2 (LRRK2) Consensus Phosphorylation Motif

Mutations in LRRK2 (leucine-rich repeat kinase 2) have been identified as major genetic determinants of Parkinson's disease (PD). The most prevalent mutation, G2019S, increases LRRK2's kinase activity, therefore understanding the sites and substrates that LRRK2 phosphorylates is critical t...

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Detalhes bibliográficos
Main Authors: Pungaliya, Pooja P., Bai, Yuchen, Lipinski, Kerri, Anand, Vasanti S., Sen, Saurabh, Brown, Eugene L., Bates, Brian, Reinhart, Peter H., West, Andrew B., Hirst, Warren D., Braithwaite, Steven P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965117/
https://ncbi.nlm.nih.gov/pubmed/21060682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013672
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