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Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities
The LRRK2 protein has both GTPase and kinase activities and mutation in either enzymatic domain can cause late-onset Parkinson’s disease (PD). Nucleotide binding in the GTPase domain may be required for kinase activity and residues in the GTPase domain are potential sites for autophosphorylation, su...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3158845/ https://ncbi.nlm.nih.gov/pubmed/21806997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.07.033 |
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