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LRRK2 autophosphorylation enhances its GTPase activity

The leucine-rich repeat kinase (LRRK)-2 protein contains nonoverlapping GTPase and kinase domains, and mutation in either domain can cause Parkinson disease. GTPase proteins are critical upstream modulators of many effector protein kinases. In LRRK2, this paradigm may be reversed, as the kinase doma...

詳細記述

保存先:
書誌詳細
出版年:FASEB J
主要な著者: Liu, Zhiyong, Mobley, James A., DeLucas, Lawrence J., Kahn, Richard A., West, Andrew B.
フォーマット: Artigo
言語:Inglês
出版事項: Federation of American Societies for Experimental Biology 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684519/
https://ncbi.nlm.nih.gov/pubmed/26396237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-277095
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