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LRRK2 autophosphorylation enhances its GTPase activity
The leucine-rich repeat kinase (LRRK)-2 protein contains nonoverlapping GTPase and kinase domains, and mutation in either domain can cause Parkinson disease. GTPase proteins are critical upstream modulators of many effector protein kinases. In LRRK2, this paradigm may be reversed, as the kinase doma...
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| Publicado no: | FASEB J |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Federation of American Societies for Experimental Biology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4684519/ https://ncbi.nlm.nih.gov/pubmed/26396237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-277095 |
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