Protective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity

Mutations in LRRK2 are a common cause of familial and idiopathic Parkinson’s disease (PD). Recently, the LRRK2 GTPase domain R1398H variant was suggested in genetic studies to confer protection against PD but mechanistic data supporting this is lacking. Here, we present evidence that R1398H affects...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Nixon-Abell, Jonathon, Berwick, Daniel C., Grannó, Simone, Spain, Victoria A., Blackstone, Craig, Harvey, Kirsten
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4781896/
https://ncbi.nlm.nih.gov/pubmed/27013965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2016.00018
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