Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling

BACKGROUND: LRRK2 mutations and risk variants increase susceptibility to inherited and idiopathic Parkinson’s disease, while recent studies have identified potential protective variants. This, and the fact that LRRK2 mutation carriers develop symptoms and brain pathology almost indistinguishable fro...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Principais autores: Berwick, Daniel C., Javaheri, Behzad, Wetzel, Andrea, Hopkinson, Mark, Nixon-Abell, Jonathon, Grannò, Simone, Pitsillides, Andrew A., Harvey, Kirsten
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5248453/
https://ncbi.nlm.nih.gov/pubmed/28103901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0153-4
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