Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling

BACKGROUND: LRRK2 mutations and risk variants increase susceptibility to inherited and idiopathic Parkinson’s disease, while recent studies have identified potential protective variants. This, and the fact that LRRK2 mutation carriers develop symptoms and brain pathology almost indistinguishable fro...

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Bibliographic Details
Published in:Mol Neurodegener
Main Authors: Berwick, Daniel C., Javaheri, Behzad, Wetzel, Andrea, Hopkinson, Mark, Nixon-Abell, Jonathon, Grannò, Simone, Pitsillides, Andrew A., Harvey, Kirsten
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5248453/
https://ncbi.nlm.nih.gov/pubmed/28103901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0153-4
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