Protective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity

Mutations in LRRK2 are a common cause of familial and idiopathic Parkinson’s disease (PD). Recently, the LRRK2 GTPase domain R1398H variant was suggested in genetic studies to confer protection against PD but mechanistic data supporting this is lacking. Here, we present evidence that R1398H affects...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Mol Neurosci
Egile Nagusiak: Nixon-Abell, Jonathon, Berwick, Daniel C., Grannó, Simone, Spain, Victoria A., Blackstone, Craig, Harvey, Kirsten
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2016
Gaiak:
Neuroscience
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4781896/
https://ncbi.nlm.nih.gov/pubmed/27013965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2016.00018
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