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Dependence of Leucine-rich Repeat Kinase 2 (LRRK2) Kinase Activity on Dimerization
Dominant missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common known genetic cause of Parkinson disease. LRRK2 encodes a serine/threonine protein kinase, and pathogenic mutations may increase kinase activity. Intrinsic GTP binding in the GTPase domain may govern kin...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2794750/ https://ncbi.nlm.nih.gov/pubmed/19826009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.025437 |
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