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Urinary LRRK2 phosphorylation predicts parkinsonian phenotypes in G2019S LRRK2 carriers
OBJECTIVE: To test whether phosphorylated Ser-1292 LRRK2 levels in urine exosomes predicts LRRK2 mutation carriers (LRRK2+) and noncarriers (LRRK2−) with Parkinson disease (PD+) and without Parkinson disease (PD−). METHODS: LRRK2 protein was purified from urinary exosomes collected from participants...
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| Published in: | Neurology |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Lippincott Williams & Wilkins
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4799717/ https://ncbi.nlm.nih.gov/pubmed/26865512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000002436 |
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