Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia

BACKGROUND: α-Synuclein (αSYN) has been genetically implicated in familial and sporadic Parkinson’s disease (PD), and is associated with disease susceptibility, progression and pathology. Excess amounts of αSYN are toxic to neurons. In the brain, microglial αSYN clearance is closely related to neuro...

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Foilsithe in:BMC Neurosci
Main Authors: Maekawa, Tatsunori, Sasaoka, Toshikuni, Azuma, Sadahiro, Ichikawa, Takafumi, Melrose, Heather L., Farrer, Matthew J., Obata, Fumiya
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2016
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5131420/
https://ncbi.nlm.nih.gov/pubmed/27903237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12868-016-0315-2
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