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Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia
BACKGROUND: α-Synuclein (αSYN) has been genetically implicated in familial and sporadic Parkinson’s disease (PD), and is associated with disease susceptibility, progression and pathology. Excess amounts of αSYN are toxic to neurons. In the brain, microglial αSYN clearance is closely related to neuro...
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| Publicado no: | BMC Neurosci |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5131420/ https://ncbi.nlm.nih.gov/pubmed/27903237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12868-016-0315-2 |
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