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Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons
Missense mutations in the multi-domain kinase LRRK2 cause late onset familial Parkinson’s disease. They most commonly with classic proteinopathy in the form of Lewy bodies and Lewy neurites comprised of insoluble α-synuclein, but in rare cases can also manifest tauopathy. The normal function of LRRK...
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| Vydáno v: | Neurobiol Dis |
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| Hlavní autoři: | , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5803451/ https://ncbi.nlm.nih.gov/pubmed/29246723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2017.12.005 |
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