Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons

Missense mutations in the multi-domain kinase LRRK2 cause late onset familial Parkinson’s disease. They most commonly with classic proteinopathy in the form of Lewy bodies and Lewy neurites comprised of insoluble α-synuclein, but in rare cases can also manifest tauopathy. The normal function of LRRK...

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Udgivet i:Neurobiol Dis
Main Authors: Schapansky, Jason, Khasnavis, Saurabh, DeAndrade, Mark P., Nardozzi, Jonathan D., Falkson, Samuel R., Boyd, Justin D., Sanderson, John B., Bartels, Tim, Melrose, Heather L., LaVoie, Matthew J.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5803451/
https://ncbi.nlm.nih.gov/pubmed/29246723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2017.12.005
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