ER stress response plays an important role in aggregation of α-synuclein

BACKGROUND: Accumulation of filamentous α-synuclein as Lewy bodies is a hallmark of Parkinson's disease. To identify the mechanisms involved in α-synuclein assembly and determine whether the assemblies are cytotoxic, we developed a cell model (3D5) that inducibly expresses wild-type human α-syn...

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Main Authors: Jiang, Peizhou, Gan, Ming, Ebrahim, Abdul Shukkur, Lin, Wen-Lang, Melrose, Heather L, Yen, Shu-Hui C
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2010
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3016345/
https://ncbi.nlm.nih.gov/pubmed/21144044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-56
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