Heterogeneity of Leucine-Rich Repeat Kinase 2 Mutations: Genetics, Mechanisms and Therapeutic Implications

Por Rudenko, Iakov N., Cookson, Mark R.
Publicado no Neurotherapeutics (2014)

Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?

Por Rudenko, Iakov N, Chia, Ruth, Cookson, Mark R
Publicado em 2012

The function of orthologues of the human Parkinson’s disease gene LRRK2 across species: implications for disease modeling in preclinical research

Por Langston, Rebekah G., Rudenko, Iakov N., Cookson, Mark R.
Publicado no Biochem J (2016)

Hexokinase activity is required for recruitment of parkin to depolarized mitochondria

Por McCoy, Melissa K., Kaganovich, Alice, Rudenko, Iakov N., Ding, Jinhui, Cookson, Mark R.
Publicado em 2014

The G2385R Variant of Leucine-Rich Repeat Kinase 2 Associated with Parkinson's Disease is a Partial Loss of Function Mutation

Por Rudenko, Iakov N., Kaganovich, Alice, Hauser, David N., Beylina, Aleksandra, Chia, Ruth, Ding, Jinhui, Maric, Dragan, Jaffe, Howard, Cookson, Mark R.
Publicado no Biochem J (2012)

The G2385R risk factor for Parkinson’s disease enhances CHIP-dependent intracellular degradation of LRRK2

Por Rudenko, Iakov N., Kaganovich, Alice, Langston, Rebekah G., Beilina, Aleksandra, Ndukwe, Kelechi, Kumaran, Ravindran, Dillman, Allissa A., Chia, Ruth, Cookson, Mark R.
Publicado no Biochem J (2017)

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

Por Chia, Ruth, Haddock, Sara, Beilina, Alexandra, Rudenko, Iakov N, Mamais, Adamantios, Kaganovich, Alice, Li, Yan, Kumaran, Ravindran, Nalls, Michael A, Cookson, Mark R
Publicado no Nat Commun (2014)

Messenger RNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex

Por Dillman, Allissa A., Hauser, David N., Gibbs, J. Raphael, Nalls, Michael A., McCoy, Melissa K., Rudenko, Iakov N., Galter, Dagmar, Cookson, Mark R.
Publicado em 2013

Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation

Por Liu, Guoxiang, Yu, Jia, Ding, Jinhui, Xie, Chengsong, Sun, Lixin, Rudenko, Iakov, Zheng, Wang, Sastry, Namratha, Luo, Jing, Rudow, Gay, Troncoso, Juan C., Cai, Huaibin
Publicado em 2014

Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle

Por Lobbestael, Evy, Zhao, Jing, Rudenko, Iakov N., Beylina, Aleksandra, Gao, Fangye, Wetter, Justin, Beullens, Monique, Bollen, Mathieu, Cookson, Mark R., Baekelandt, Veerle, Nichols, R. Jeremy, Taymans, Jean-Marc
Publicado no Biochem J (2013)

Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice

Por Pellegrini, Laura, Hauser, David N, Li, Yan, Mamais, Adamantios, Beilina, Alexandra, Kumaran, Ravindran, Wetzel, Andrea, Nixon-Abell, Jonathon, Heaton, George, Rudenko, Iakov, Alkaslasi, Mor, Ivanina, Natalie, Melrose, Heather L, Cookson, Mark R, Harvey, Kirsten
Publicado no Hum Mol Genet (2018)

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

Por Beilina, Alexandria, Rudenko, Iakov N., Kaganovich, Alice, Civiero, Laura, Chau, Hien, Kalia, Suneil K., Kalia, Lorraine V., Lobbestael, Evy, Chia, Ruth, Ndukwe, Kelechi, Ding, Jinhui, Nalls, Mike A., Olszewski, Maciej, Hauser, David N., Kumaran, Ravindran, Lozano, Andres M., Baekelandt, Veerle, Greene, Lois E., Taymans, Jean-Marc, Greggio, Elisa, Cookson, Mark R., Nalls, Mike A., Plagnol, Vincent, Martinez, Maria, Hernandez, Dena G, Sharma, Manu, Sheerin, Una-Marie, Saad, Mohamad, Simón-Sánchez, Javier, Schulte, Claudia, Lesage, Suzanne, Sveinbjörnsdóttir, Sigurlaug, Arepalli, Sampath, Barker, Roger, Ben-Shlomo, Yoav, Berendse, Henk W, Berg, Daniela, Bhatia, Kailash, de Bie, Rob M A, Biffi, Alessandro, Bloem, Bas, Bochdanovits, Zoltan, Bonin, Michael, Bras, Jose M, Brockmann, Kathrin, Brooks, Janet, Burn, David J, Charlesworth, Gavin, Chen, Honglei, Chong, Sean, Clarke, Carl E, Cookson, Mark R, Cooper, J Mark, Corvol, Jean Christophe, Counsell, Carl, Damier, Philippe, Dartigues, Jean-François, Deloukas, Panos, Deuschl, Günther, Dexter, David T, van Dijk, Karin D, Dillman, Allissa, Durif, Frank, Dürr, Alexandra, Edkins, Sarah, Evans, Jonathan R, Foltynie, Thomas, Gao, Jianjun, Gardner, Michelle, Gibbs, J Raphael, Goate, Alison, Gray, Emma, Guerreiro, Rita, Gústafsson, Ómar, Harris, Clare, van Hilten, Jacobus J, Hofman, Albert, Hollenbeck, Albert, Holton, Janice, Hu, Michele, Huang, Xuemei, Huber, Heiko, Hudson, Gavin, Hunt, Sarah E, Huttenlocher, Johanna, Illig, Thomas, München, Helmholtz Zentrum, Jónsson, Pálmi V, Lambert, Jean-Charles, Langford, Cordelia, Lees, Andrew, Lichtner, Peter, München, Helmholtz Zentrum, Limousin, Patricia, Lopez, Grisel, Lorenz, Delia, McNeill, Alisdair, Moorby, Catriona, Moore, Matthew, Morris, Huw R, Morrison, Karen E, Mudanohwo, Ese, O’Sullivan, Sean S, Pearson, Justin, Perlmutter, Joel S, Pétursson, Hjörvar, Pollak, Pierre, Post, Bart, Potter, Simon, Ravina, Bernard, Revesz, Tamas, Riess, Olaf, Rivadeneira, Fernando, Rizzu, Patrizia, Ryten, Mina, Sawcer, Stephen, Schapira, Anthony, Scheffer, Hans, Shaw, Karen, Shoulson, Ira, Sidransky, Ellen, Smith, Colin, Spencer, Chris C A, Stefánsson, Hreinn, Steinberg, Stacy, Stockton, Joanna D, Strange, Amy, Talbot, Kevin, Tanner, Carlie M, Tashakkori-Ghanbaria, Avazeh, Tison, François, Trabzuni, Daniah, Traynor, Bryan J, Uitterlinden, André G, Velseboer, Daan, Vidailhet, Marie, Walker, Robert, van de Warrenburg, Bart, Wickremaratchi, Mirdhu, Williams, Nigel, Williams-Gray, Caroline H, Winder-Rhodes, Sophie, Stefánsson, Kári, Hardy, John, Heutink, Peter, Brice, Alexis, Gasser, Thomas, Singleton, Andrew B, Wood, Nicholas W, Chinnery, Patrick F, Arepalli, Sampath, Cookson, Mark R, Dillman, Allissa, Ferrucci, Luigi, Gibbs, J Raphael, Hernandez, Dena G, Johnson, Robert, Longo, Dan L, Majounie, Elisa, Nalls, Michael A, O’Brien, Richard, Singleton, Andrew B, Traynor, Bryan J, Troncoso, Juan, van der Brug, Marcel, Zielke, H Ronald, Zonderman, Alan B
Publicado em 2014