The G2385R risk factor for Parkinson’s disease enhances CHIP-dependent intracellular degradation of LRRK2

Autosomal dominant mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson’s disease (PD). Most pathogenic LRRK2 mutations result in amino acid substitutions in the central ROC (Ras of complex proteins)–C-terminus of ROC–kinase triple domain and affect enzymatic functions of...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Rudenko, Iakov N., Kaganovich, Alice, Langston, Rebekah G., Beilina, Aleksandra, Ndukwe, Kelechi, Kumaran, Ravindran, Dillman, Allissa A., Chia, Ruth, Cookson, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6178381/
https://ncbi.nlm.nih.gov/pubmed/28320779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20160909
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