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The G2385R risk factor for Parkinson’s disease enhances CHIP-dependent intracellular degradation of LRRK2

Autosomal dominant mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson’s disease (PD). Most pathogenic LRRK2 mutations result in amino acid substitutions in the central ROC (Ras of complex proteins)–C-terminus of ROC–kinase triple domain and affect enzymatic functions of...

詳細記述

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書誌詳細
出版年:Biochem J
主要な著者: Rudenko, Iakov N., Kaganovich, Alice, Langston, Rebekah G., Beilina, Aleksandra, Ndukwe, Kelechi, Kumaran, Ravindran, Dillman, Allissa A., Chia, Ruth, Cookson, Mark R.
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6178381/
https://ncbi.nlm.nih.gov/pubmed/28320779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20160909
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