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The G2385R risk factor for Parkinson’s disease enhances CHIP-dependent intracellular degradation of LRRK2
Autosomal dominant mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson’s disease (PD). Most pathogenic LRRK2 mutations result in amino acid substitutions in the central ROC (Ras of complex proteins)–C-terminus of ROC–kinase triple domain and affect enzymatic functions of...
Shranjeno v:
| izdano v: | Biochem J |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6178381/ https://ncbi.nlm.nih.gov/pubmed/28320779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20160909 |
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