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Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial Parkinson's disease (PD). Variation around the LRRK2 locus also contributes to the risk of sporadic PD. The LRRK2 protein contains a central catalytic region, and pathogenic mutations cluster in the Ras of...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3308210/ https://ncbi.nlm.nih.gov/pubmed/22361010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7015-10-20 |
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