Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial Parkinson's disease (PD). Variation around the LRRK2 locus also contributes to the risk of sporadic PD. The LRRK2 protein contains a central catalytic region, and pathogenic mutations cluster in the Ras of...

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Hlavní autoři: Rudenko, Iakov N, Chia, Ruth, Cookson, Mark R
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
Témata:
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308210/
https://ncbi.nlm.nih.gov/pubmed/22361010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7015-10-20
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