RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase–mediated centrosomal cohesion and ciliogenesis deficits

Mutations in the LRRK2 kinase are the most common cause of familial Parkinson’s disease, and variants increase risk for the sporadic form of the disease. LRRK2 phosphorylates multiple RAB GTPases including RAB8A and RAB10. Phosphorylated RAB10 is recruited to centrosome-localized RILPL1, which may i...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Lara Ordónez, Antonio Jesús, Fernández, Belén, Fdez, Elena, Romo-Lozano, María, Madero-Pérez, Jesús, Lobbestael, Evy, Baekelandt, Veerle, Aiastui, Ana, López de Munaín, Adolfo, Melrose, Heather L, Civiero, Laura, Hilfiker, Sabine
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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General Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927464/
https://ncbi.nlm.nih.gov/pubmed/31428781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz201
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