Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity

Parkinson’s disease-linked mutations in LRRK2 enhance the kinase activity of the protein, therefore targeting LRRK2 kinase activity is a promising therapeutic approach. Phosphorylation at S935 of LRRK2 and of its Rab GTPase substrates have proven very useful biomarkers to monitor its kinase activity...

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Dettagli Bibliografici
Pubblicato in:NPJ Parkinsons Dis
Autori principali: Kluss, Jillian H., Conti, Melissa M., Kaganovich, Alice, Beilina, Aleksandra, Melrose, Heather L., Cookson, Mark R., Mamais, Adamantios
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
Soggetti:
Brief Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908918/
https://ncbi.nlm.nih.gov/pubmed/29707617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41531-018-0049-1
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